Meskacel™ L-HPC LP21 power is a high-quality pharmaceutical excipient, widely used in the production of tablets and capsules, mainly as a disintegrant and binder. It has a highly efficient disintegration performance. The surface of the crystal particles is rough. It has a structure similar to weathered rock, which can rapidly absorb moisture, causing the tablets to expand quickly and disintegrate into uniform powder, thereby increasing the disintegration rate and bioavailability. In addition, it also has excellent adhesion. Its rough structure gives it a strong inlaying effect with drugs and particles, increasing adhesion, enhancing the hardness and gloss of tablets, and improving the moulding effect.
As a nonionic polymer, L-HPC LP21 power has stable chemical properties, is not prone to chemical reactions with drugs, has little impact on the therapeutic effect of drugs, contains no peroxides, and cooperates well with oxygen-sensitive active drug components, ensuring the quality and stability of drugs. Meanwhile, it can be used as a disintegrant or binder in both wet and dry granulation methods and is widely adaptable. Generally, the usage concentration in prescriptions is 5%-25%.
L-HPC LP21 Low-Substituted Ether Of Cellulose (L-HPC) | |
| Main Source of Materials | Cotton and Wood Pulp |
| CAS NO. | 9004-64-2 |
| HS Code | 39129000 |
Type | Pharmaceutical Excipients |
Physical Analysis | |
| Appearance | White or off-white fibrous or granular powder |
| Applications | Tablet anti-capping agent, tablet dry binder, tablet rapid disintegrator, dispersion aid (for capsule filling) |
| Formula Modification | Support |
| Packing | IN FIBER DRUMS WITH INNER P.E. BAGS, NET WEIGHT 25 KG PER DRUM. |
Chemical Analysis | |
| Hydroxypropoxy | 10.0-12.9 |
| Chloride | ≤0.36 |
| Residue on ignition | ≤0.5 |
| Loss on drying | ≤5.0 |
| Residue on ignition | ≤0.5 |
| Particle Size(μm) | 40 |
| Particle Type | Highly Fibrous |
Method of Application | Direct Compression(Anti-capping) |
Standard tablets play the dual roles of binder and disintegrant simultaneously, ensuring that they are aesthetically pleasing in formation and disintegrate rapidly. For example, in the production of acetaminophen tablets, L-HPC LP21 can optimise the process and enhance product stability.
Dispersed tablets: The tablets' rapid disintegration property allows them to be quickly dispersed into uniform particles in water, making them convenient for children and elderly patients to take and improving medication compliance.
Sustained-release formulation framework material: Its controllable expansion property (expansion rate 300%-500%), when combined with ethyl cellulose (EC), enables zero-level drug release within 12-24 hours. Experimental data show that the deviation rate of drug release after compatibility is less than 5%.
Optimisation of disintegration of poorly soluble drugs: L-HPC LP21 significantly shortens the dissolution time through the synergistic effect of capillary permeation and dilation. For example, the dissolution rate in metformin tablets increased from 60% (starch system) to 95% (LP21 system).
Strict quality control: The production of our pharmaceutical-grade L-HPC LP21 power strictly follows international pharmacopeia standards. We control the source of raw materials, select high-quality cotton lint or wood pulp, and go through multiple purification and modification processes to ensure the purity of the products. The finished product needs to pass 12 strict tests, including hydroxypropyl content (5%-7%), loss on drying (≤5.0%), microbial limit (meeting the requirements of sterile preparations), etc.
Stable product supply: With its large production capacity (38,000 tons per year), it can meet customers' large-scale purchasing demands and ensure timely delivery.
Perfect customized services: Provide customized L-HPC LP21 power products and services. Parameters such as particle size and degree of substitution of the products can be adjusted according to the customer's specific requirements to meet their personalized needs.
Contact us immediately to get customized solutions and free samples and unlock new possibilities for efficient preparations!
LP21 has a lower degree of substitution (≤21% vs ≤22%) and a higher viscosity (20-40 mPa·s vs 15-30 mPa·s), making it more suitable for high-drug loading tablets and sustained-release skeleton applications.
When storing L-HPC LP21, pay attention to the following points:
