Medical-grade Meskacel™ HPMC E15 powder is a low-viscosity hydroxypropyl methyl cellulose designed to meet various pharmaceutical excipient requirements. It is a white to slightly yellow fibrous or granular powder with a rich application history in the medical field. As a film coating agent, adhesive, release blocker, etc., it can significantly improve the stability and dissolution rate of drugs and enhance the water resistance of tablets. Its unique properties make it a key excipient in many medical preparations.
HPMC E15 Hydroxypropyl Methyl Cellulose (HPMC) | |
| Main Source of Materials | Cotton and Wood Pulp |
| CAS NO. | 9004-65-3 |
HS Code | 39123900 |
Type | Pharmaceutical Excipients |
Physical Analysis | |
| Appearance | White or off-white fibrous or granular powder |
| Applications | Tablet Coating, Capsule, Controlled Release, Disintegrant, etc. |
| Formula Modification | Support |
| Packing | IN FIBER DRUMS WITH INNER P.E. BAGS, NET WEIGHT 25 KG PER DRUM. |
Chemical Analysis | |
| Methoxy | 28.0-30.0 |
| Hydroxypropoxy | 7.0-12.0 |
| Gelation Temperature(℃) | 58.0-64.0 |
| Viscosity (mPa.s) | 15 |
| Loss on drying | ≤5.0 |
| Residue on ignition | ≤1.5 |
| PH | 4.0-8.0 |
Microbiological Limit | |
Total microbe count | ≤1000cfu/g |
Total mold and yeast | ≤100cfu/g |
Escherichia coli | 0 |
Tablet application: In tablet production, medical-grade HPMC E15 is a highly effective adhesive that can help enhance the hardness and stability of tablets, making them less prone to breakage and loosening during storage and transportation. Meanwhile, it also has good disintegration performance, which is conducive to the rapid disintegration of tablets in the body and the release of drugs. For example, in some oral tablets, adding an appropriate amount of HPMC E15 can improve the tablets' formability, production efficiency, and product quality.
Application of sustained-release preparations: It can prepare hydrophilic gel skeleton sustained-release and controlled-release systems. By adjusting the dosage and formula of HPMC E15, the release rate of the drug can be controlled, achieving a slow and continuous release of the drug, thereby prolonging the action time of the drug in the body and improving the therapeutic effect of the drug and the medication compliance of patients. For example, in some sustained-release tablets for treating chronic diseases, HPMC E15 serves as the skeletal material, enabling the drug to be continuously released for several hours or even days, reducing the frequency of medication for patients.
Film coating application: It is a film coating material with excellent performance that can form a uniform, smooth, and tough film coating on the surface of tablets, pills, etc. This film coating can not only improve the appearance of the preparation, enhance its aesthetic appeal and stability, but also play a role in moisture-proofing, light-blocking and odour-masking, thereby extending the validity period of the preparation. Taking film-coated tablets as an example, after coating with HPMC E15, the dissolution behaviour of the preparation in the gastrointestinal tract is more controllable, and the bioavailability of the drug has also been improved.
Ophthalmic application: In ophthalmic eye drops, medical-grade HPMC E15 can be used as a viscosity enhancer to increase the viscosity of the eye drops, prolong their residence time in the eye, and enhance the contact opportunities between the drug and the cornea and conjunctiva, thereby enhancing the therapeutic effect of the drug. Generally, HPMC E15 with a concentration of 0.45%-1.0% can achieve an ideal viscosity-increasing effect without causing irritation or adverse eye reactions.
Other applications: It can also be used as a suspending agent in liquid pharmaceuticals to enhance the suspension stability of drug particles and prevent drug sedimentation and aggregation. It is used as an emulsifier to prepare emulsions, increase their stability, and avoid the separation of the oil phase and the water phase. It is a stabiliser in some drug preparations sensitive to light, heat, oxygen, etc., to improve their stability.
High safety: Medical-grade Meskacel™ HPMC E15 powder, as a pharmaceutical excipient, has undergone strict quality inspection and safety assessment. It is a non-toxic and non-irritating material. Ordinary intake is harmless to human health and can be used in various oral and topical drug preparations.
Good stability: Its properties are stable. The solution is stable at pH 2- 8. The viscosity of the solution decreases as the temperature increases. Heating - cooling can reverse the transformation of Meskacel™ HPMC E15 powder from the solution state to the gel state. Moreover, its aqueous solution has an anti-enzyme effect and can maintain good viscosity stability during long-term storage, which is conducive to the preservation and use of the preparation.
Excellent compatibility: Meskacel™ HPMC E15 powder is a nonionic cellulose ether. Its solution does not carry ionic charges, react with metal salts or ionic organic compounds, or react with other raw materials and excipients during the formulation production process. It has strong anti-allergy properties and can be compatible with various drugs and excipients without affecting the activity and efficacy of the drugs.
Strong versatility: It possesses the functions of multiple pharmaceutical excipients, such as adhesives, release blockers, coating materials, thickeners, suspending agents, and emulsifiers. It can be selected and applied according to different formulation requirements, thereby enhancing the formulation's development efficiency and quality control level.
Meska Chemical has a history of over 20 years in the production and sales of pharmaceutically grade HPMC, with rich experience, an annual output of 38,000 tons, and a sufficient supply. Our Meskacel™ HPMC E15 powder is strictly produced in accordance with international pharmacopoeia standards, and the price of medical-grade HPMC E15 is also quite friendly. The professional team provides 24-hour advance service. Welcome to consult!
Hydroxypropyl methylcellulose (HPMC) is a material widely used in fields such as food, pharmaceuticals and cosmetics. According to existing research and data, HPMC is considered safe and usually does not cause serious side effects. However, during use, attention should still be paid to possible allergic reactions, eye irritation and other issues. You should consult a doctor promptly if any discomfort symptoms occur after using HPMC.
There are many differences between E and K in medical-grade HPMC. Chemically, they are all produced by the reaction of cellulose with propylene oxide and chloromethane. Still, the proportions of hydroxypropyl and methoxy groups are different, with a higher content of K-type methoxy groups. Regarding physical properties, type E has better water solubility and dissolves faster. Its viscosity is lower than type K. Type K has multiple viscosity grades and a higher gel point. In application fields, Type E is commonly used as a coating adhesive for tablets, etc.. At the same time, Type K is more suitable for controlled-release preparations, as it enables drugs to be released slowly. In conclusion, the appropriate type should be selected based on the specific requirements of the drug preparation.
